Synergetic Enhancing Effects between Platinum Nanosensitizers and Clinically Approved Stabilizing Ligands in Proton Therapy, Causing High‐Yield Double‐Strand Breaks of Plasmid DNA at Relevant Dose

Proton therapy is used to eradicate tumors in sensitive areas by targeted delivery of energy. Its effectiveness can be amplified using nanoparticles (NPs) as sensitizers, due to the production of reactive oxygen species at the NP's catalytically active surface, causing the cleavage of DNA. However,...

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Bibliografische Detailangaben

Hauptverfasser:	Sandra Zwiehoff, Astrid Hensel, Ramin Rishmawi, Parisa Shakibaei, Carina Behrends, Katrin Hommel, Christian Bäumer, Shirley Karin Knauer, Beate Timmermann, Christoph Rehbock, Stephan Barcikowski
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley-VCH 2024-11-01
Schriftenreihe:	Advanced NanoBiomed Research
Schlagworte:	albumins clustered DNA damages nanoparticles polyethylene glycol reactive oxygen species tumor therapies
Online-Zugang:	https://doi.org/10.1002/anbr.202400023
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