Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

Abstract We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patient-derived PitNET primary cells in HTS. Based on the screening results, the potenti...

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Xehetasun bibliografikoak
Egile Nagusiak:	Yijun Cheng, Yuting Dai, Hao Tang, Xingyu Lu, Jing Xie, Wanqun Xie, Qianqian Zhang, Yanting Liu, Shaojian Lin, Hong Yao, Hanbing Shang, Kun Yang, Hongyi Liu, Xuefeng Wu, Jianming Zhang, Xun Zhang, Li Xue, Zhe Bao Wu
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2024-04-01
Saila:	Acta Neuropathologica Communications
Gaiak:	PitNETs High-throughput screening HDACIs Panobinostat Nrf2
Sarrera elektronikoa:	https://doi.org/10.1186/s40478-024-01775-2
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

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