Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma

Patients with osteosarcoma (OS), a debilitating pediatric bone malignancy, have limited treatment options to combat aggressive disease. OS thrives on insulin growth factor (IGF)-mediated signaling that can facilitate cell proliferation. Previous efforts to target IGF-1R signaling were mostly unsucce...

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Hlavní autoři:	Safiya Khurshid, Akila S. Venkataramany, Matias Montes, John F. Kipp, Ryan D. Roberts, Nicolas Wein, Frank Rigo, Pin-Yi Wang, Timothy P. Cripe, Dawn S. Chandler
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-12-01
Edice:	Molecular Therapy: Oncology
Témata:	MT: Regular Issue alternative splicing insulin receptor splice-switching oligonucleotides U7 snRNA osteosarcoma
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2950329924001504
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