Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer

Abstract Background The prognosis for patients with head and neck cancer (HNC) is poor and has improved little in recent decades, partially due to lack of therapeutic options. To identify effective therapeutic targets, we sought to identify molecular pathways that drive metastasis and HNC progressio...

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Principais autores:	Kevin Brennan, Almudena Espín-Pérez, Serena Chang, Nikita Bedi, Saumyaa Saumyaa, June Ho Shin, Sylvia K. Plevritis, Olivier Gevaert, John B. Sunwoo, Andrew J. Gentles
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-11-01
Series:	Genome Medicine
Assuntos:	Head and neck cancer Lymph node metastasis Transcriptomics Meta-analysis Single-cell RNA-Seq p53-DREAM pathway
Acceso en liña:	https://doi.org/10.1186/s13073-023-01236-w
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