Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices

Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could be found. We therefore aimed to investigate the biological an...

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Bibliografski detalji

Glavni autori:	Julia Hörnschemeyer, Timo Kirschstein, Gesine Reichart, Christin Sasse, Jakob Venus, Anne Einsle, Katrin Porath, Michael Linnebacher, Rüdiger Köhling, Falko Lange
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-08-01
Serija:	Life
Teme:	glioblastoma low-passage glioblastoma cell lines ipatasertib MK-2206 dactolisib trametinib
Online pristup:	https://www.mdpi.com/2075-1729/12/8/1258
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