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Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication.

There are approximately 20 million events of hepatitis E virus (HEV) infection worldwide annually. The genome of HEV is a single-strand, positive-sense RNA containing 5' and 3' untranslated regions and three open reading frames (ORF). HEV genome has 5' cap and 3' poly(A) tail to mimic host mRNA to e...

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Huvudupphov: Xiaohui Ju, Guangtao Xiang, Mingli Gong, Rui Yang, Jierui Qin, Yafei Li, Yuchen Nan, Yonglin Yang, Qiangfeng Cliff Zhang, Qiang Ding
Materialtyp: Artigo
Språk:Inglês
Utgiven: Public Library of Science (PLoS) 2020-05-01
Serie:PLoS Pathogens
Länkar:https://doi.org/10.1371/journal.ppat.1008488
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