Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapy

IntroductionIn people with HIV (PWH) both off and on antiretroviral therapy (ART), the expression of immune checkpoint (IC) proteins is elevated on the surface of total and HIV-specific T-cells, indicating T-cell exhaustion. Soluble IC proteins and their ligands can also be detected in plasma, but h...

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Bibliografiska uppgifter

Huvudupphov:	Chris Y. Chiu, Maya D. Schou, James H. McMahon, Steven G. Deeks, Rémi Fromentin, Nicolas Chomont, Michelle N. Wykes, Thomas A. Rasmussen, Sharon R. Lewin
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2023-03-01
Serie:	Frontiers in Immunology
Ämnen:	HIV soluble immune checkpoint immunotherapy immune checkpoint blockade HIV reservoir HIV-specific T-cell function
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123342/full
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