Pantothenate kinase 4 controls lipid synthesis for T-cell proliferation by modulating coenzyme A and glutaminolysis

Abstract During T-cell-mediated inflammatory responses, T cells are activated upon recognizing specific antigens presented by antigen-presenting cells. This recognition initiates signaling through the TCR and CD28, leading to their activation and subsequent clonal expansion. Within the signaling cas...

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Detalhes bibliográficos

Principais autores:	Jeong-Ryul Hwang, Chi Thi Ngoc Nguyen, Gwanghoon Ko, Jung-Ah Kang, Yeongseon Byeon, Seowoo Park, Ryunha Chang, Dawoon Jung, Mi Yeon Jeon, Young Hoon Sung, Cho-Rong Lee, Ki-Hoan Nam, Je Kyung Seong, Sankar Ghosh, Yun Pyo Kang, Sung-Gyoo Park
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2025-09-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-025-02385-7
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