Refining the adriamycin‐induced focal segmental glomerulosclerosis mouse model to improve reproducibility and animal welfare

Abstract Background Reliable animal models are crucial to drug development for focal segmental glomerulosclerosis (FSGS), a rare kidney disease. Variability in success rates in literature and significant ethical concerns with animal welfare necessitate further optimization of adriamycin (ADR)–induce...

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Autori principali:	Haochen Jiang, Salma Althobaiti, Braeden Pinkerton, Xin Fu, Zhenshan Jia, Kirk W. Foster, Geoffrey M. Thiele, Troy J. Plumb, Dong Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-05-01
Serie:	Animal Models and Experimental Medicine
Soggetti:	adriamycin (ADR) focal segmental glomerulosclerosis (FSGS) instability kidney standard operating procedure (SOP)
Accesso online:	https://doi.org/10.1002/ame2.12564
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