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Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

Abstract Background Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms by which ovarian cancer cells acquire CDDP resistance. Methods We evalua...

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Principais autores: Jing Guo, Kiyotoshi Satoh, Sho Tabata, Masaru Mori, Masaru Tomita, Tomoyoshi Soga
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-02-01
Serier:BMC Cancer
Fag:
Ovarian cancer
Cisplatin resistance
Glutamine synthetase
Metabolome
CE-TOFMS
Online adgang:https://doi.org/10.1186/s12885-021-07879-5
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