Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the proces...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2021-04-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-021-21354-6 |
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