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Maternal Western diet programs cardiometabolic dysfunction and hypothalamic inflammation via epigenetic mechanisms predominantly in the male offspring

Objective: Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) prog...

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Principais autores: Mona Elgazzaz, Clara Berdasco, Jone Garai, Melody Baddoo, Shiping Lu, Hisham Daoud, Jovanny Zabaleta, Franck Mauvais-Jarvis, Eric Lazartigues
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-02-01
coleção:Molecular Metabolism
Assuntos:
Maternal nutrition
Hypothalamus
Cardiometabolic disease
Epigenetics
Methylation
miRNA regulation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2212877823001989
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