AI-based analysis of label-free live cell imaging of T-cell mediated tumor killing assay enables competitive and robust hit calling

For the discovery and optimization of personalized cancer treatments using immune cell therapeutics, such as T-cell receptor (TCR-T) therapy and bispecific antibodies (BsAbs), robust functional activity of candidates must be confirmed in immune-mediated killing assays. In these assays, co-cultures o...

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Hlavní autoři:	Josefa dela Cruz-Chuh, Daniel Siegismund, John Moffat, Stephan Heyse, Katherine R. Kozak, Stephan Steigele
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-04-01
Edice:	SLAS Discovery
Témata:	Label-free imaging T cell killing assay Bispecific antibodies TCR-based therapy AI-based analysis
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2472555226000031
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