The Niemann-Pick C1 protein in recycling endosomes of presynaptic nerve terminals
Niemann-Pick type C (NPC) disease is a fatal, neurodegenerative disorder caused in 95% of cases by loss of function of NPC1, a ubiquitous endosomal transmembrane protein. A biochemical hallmark of NPC deficiency is cholesterol accumulation in the endocytic pathway. Although cholesterol trafficking d...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2006-03-01
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| Serier: | Journal of Lipid Research |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S002222752033604X |
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