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CD25+CD27+CD70− alloantigen-specific Tregs: promising stable immunotherapy for transplantation

The clinical translation of alloantigen-specific regulatory T cells (AS-Tregs) is constrained by their low frequency in peripheral blood, limited purity, and functional instability following prolonged ex vivo expansion. To address these hurdles, we developed a strategy to isolate and expand a functi...

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Autores principales: Arimelek Cortés-Hernández, Saúl Arteaga-Cruz, Iyari I. Martínez Iturbe, Katya Rosas-Cortina, Marco A. Vigil Mora, Erick Legorreta-Anguiano, Judith E. Reyes Barrientos, Evelyn K. Álvarez-Salazar, Alejandra Cervera, Beatriz E. Sánchez-Hernández, Armando Gamboa Domínguez, Gloria Soldevila
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2026-06-01
Colección:Frontiers in Immunology
Materias:
adoptive cell therapy
alloantigen-specific Tregs
CD27
lineage stability
transplantation
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1789008/full
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