BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.

書誌詳細

主要な著者:	Rikke D. Rasmussen, Madhavsai K. Gajjar, Lucie Tuckova, Kamilla E. Jensen, Apolinar Maya-Mendoza, Camilla B. Holst, Kjeld Møllgaard, Jane S. Rasmussen, Jannick Brennum, Jiri Bartek, Martin Syrucek, Eva Sedlakova, Klaus K. Andersen, Marie H. Frederiksen, Petra Hamerlik
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2016-11-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/ncomms13398
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