Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Abstract Background Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1 mut ) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to their newly acquired function: synthesis of 2-hydrox...

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Detalhes bibliográficos

Principais autores:	Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert, Mioara Larion
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-10-01
coleção:	Cancer & Metabolism
Assuntos:	IDH1-mutant Gliomas Glutaminase CB839 AGI5198 13C tracing
Acesso em linha:	http://link.springer.com/article/10.1186/s40170-020-00229-2
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