A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification

At least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain. Fatty S-acylation (prototypically, S-palmitoylation) operates across eukaryotic phylogeny and cell type. S-palmitoylation is carried out in mammal...

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Autores principales:	Naoko Adachi, Douglas T. Hess, Takehiko Ueyama
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-02-01
Colección:	Journal of Lipid Research
Materias:	cell signaling enzymology-enzyme regulation palmitoylation acyltransferase cancer mutations fatty acyl-CoA
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227525000033
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