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Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T

Abstract NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) method to quantify these metabolites in human skeletal muscle on a clinical...

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Autori principali: Julian Mevenkamp, Yvonne M. H. Bruls, Rodrigo Mancilla, Lotte Grevendonk, Joachim E. Wildberger, Kim Brouwers, Matthijs K. C. Hesselink, Patrick Schrauwen, Joris Hoeks, Riekelt H. Houtkooper, Mijke Buitinga, Robin A. de Graaf, Lucas Lindeboom, Vera B. Schrauwen-Hinderling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-10-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-024-53292-4
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