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The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

Abstract Background Phagocyte NADPH oxidase 2 (NOX2) is an enzyme complex responsible for reactive oxygen species (ROS) production. Chronic NOX2 activity sustains oxidative stress/damage and drives neuroinflammation following traumatic brain injury (TBI). NOX2 acts as a priming signal for NLRP3 infl...

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Main Authors: Janeen Laabei, Gloria Vegliante, Nathan Ryzewski Strogulski, Carly Douglas, Sahil Threja, Andrew Pearson, Aurore Nkiliza, Marie Hanscom, Isabella Dias Filogonio Emediato, Fiona Crawford, Joseph Ojo, David J. Loane
Format: Artigo
Language:Inglês
Published: BMC 2025-10-01
Series:Journal of Neuroinflammation
Subjects:
Traumatic brain injury
NOX2
Reactive oxygen species
Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome
Microglia
Inflammatory monocytes
Online Access:https://doi.org/10.1186/s12974-025-03535-y
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