Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells

Vasoactive endothelin (ET) is generated by ET converting enzyme (ECE)-induced proteolytic processing of pro-molecule big ET to biologically active peptides. H2O2 has been shown to increase the expression of ECE1 via transactivation of its promoter. The present study demonstrates that H2O2 triggered...

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Principais autores:	Ravi Kumar, Hitesh Soni, Jeremiah M. Afolabi, Praghalathan Kanthakumar, Pratheesh D. Mankuzhy, Samson A. Iwhiwhu, Adebowale Adebiyi
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2022-09-01
叢編:	Redox Biology
主題:	Mechanical stretch Urinary tract obstruction Hydrogen peroxide Endothelin converting enzyme Endothelin Acute kidney injury
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2213231722001665
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