Chenodeoxycholic acid improves oocyte maturation and embryo quality during bisphenol A exposure by activating the EGFR-ERK1/2 signaling pathway

Chenodeoxycholic acid (CDCA) is a free bile acid present in the follicular fluid surrounding growing oocytes. In this study, we demonstrate that supplementation with CDCA activates the EGFR signaling in cumulus-oocyte complexes (COCs) to improve oocyte quality. Bisphenol A (BPA), a well-documented e...

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Autors principals:	Zhi-Yong An, Tuo Zhang, Gao-Jie Lu, Xiaoyufan Xu, Xue Fang, Sheng-Zhong Han, Shuang-Yan Chang, Xi-Jun Yin, Lin-Hu Quan, Jin-Dan Kang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-09-01
Col·lecció:	Ecotoxicology and Environmental Safety
Matèries:	CDCA BPA EGFR cGMP cAMP Mitochondrial
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S014765132501070X
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