Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules

IntroductionIn vertebrate limb morphogenesis, wingless-related integration site (Wnt) proteins and fibroblast growth factors (Fgfs) secreted from the apical ectodermal ridge (AER) coordinate proximodistal outgrowth. Fgfs also sustain sonic hedgehog (Shh) in the zone of polarizing activity (ZPA). Shh...

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Principais autores:	Jessica C. Britton, Anett Somogyi-Leatigaga, Billy A. Watson, Endika Haro, Cassidy G. Mulder, Kari D. Kennedy, Allen M. Cooper, Kristen L. Whitley, Ruth-Love Yeboah, Jeanyoung Kim, Micah C. Yu, Jairo D. Campos, Japhet Amoah, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-02-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	Lhx2 vertebrate limb development cis-regulatory module gene regulation FGFs Wnt
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1552716/full
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