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TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas

Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PDCD1 ligand 1, PD-L1) expression and tumor-infiltrating lymphocytes (TIL)...

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Principais autores: Tsuyoshi Hamada, Thing Rinda Soong, Yohei Masugi, Keisuke Kosumi, Jonathan A. Nowak, Annacarolina da Silva, Xinmeng Jasmine Mu, Tyler S. Twombly, Hideo Koh, Juhong Yang, Mingyang Song, Li Liu, Mancang Gu, Yan Shi, Katsuhiko Nosho, Teppei Morikawa, Kentaro Inamura, Sachet A. Shukla, Catherine J. Wu, Levi A. Garraway, Xuehong Zhang, Kana Wu, Jeffrey A. Meyerhardt, Andrew T. Chan, Jonathan N. Glickman, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2018-07-01
Serier:OncoImmunology
Fag:
adaptive immunity
biomarkers
cohort studies
colorectal neoplasms
immunology
immunotherapy
molecular pathological epidemiology
survival analysis
t-lymphocytes
tumor microenvironment
Online adgang:http://dx.doi.org/10.1080/2162402X.2018.1442999
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