Discovery of Benzophenanthridine Alkaloids from <i>Zanthoxylum nitidum</i> That Target the MDM2–p53 Axis in NSCLC

<b>Background/Objectives:</b> Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancers and is a leading cause of cancer-related deaths worldwide. Pharmacological targeting of the p53–MDM2 interaction to activate wild-type p53 is a promising strategy for treating NSCLC that retain fu...

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Autori principali:	Nguyen Manh Cuong, Elizaveta Fefilova, Vu Thanh Loc, Natalia Karpova, Nguyen Xuan Ha, Alexandra Daks, Nguyen Viet Ha, Tran Thu Huong, Sergey Parfenyev, Alexander Nazarov, Oleg Semenov, Yulia Gnennaya, Olga Fedorova, Nickolai A. Barlev, Oleg Shuvalov
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-05-01
Serie:	Pharmaceuticals
Soggetti:	NSCLC p53 MDM2 snail <i>Zanthoxylum nitidum</i> (Roxb.) DC. nitidine
Accesso online:	https://www.mdpi.com/1424-8247/19/6/814
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