hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke

Abstract Background Ischemic stroke induces profound neuroinflammation, where microglial activation exacerbates secondary brain injury. Human umbilical mesenchymal stem cell-derived exosomes (hUMSC-Exos) exhibit therapeutic potential, but their mechanisms in modulating microglial responses remain in...

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Auteurs principaux:	Zengyu Zhang, Rong Ji, Zhuohang Liu, Zhiwen Jiang, Min Chu, Yong Wang, Jing Zhao
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-08-01
Collection:	Journal of Nanobiotechnology
Sujets:	hUMSC-exosomes Ischemic stroke TREM1 P38 MAPK signaling Microglia Neuroinflammation
Accès en ligne:	https://doi.org/10.1186/s12951-025-03652-z
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