AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic β-solenoid structures for repeat proteins

AlphaFold 2 (AF2) has revolutionised protein structure prediction but, like any new tool, its performance on specific classes of targets, especially those potentially under-represented in its training data, merits attention. Prompted by a highly confident prediction for a biologically meaningless, r...

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Auteurs principaux:	Olivia S. Pratt, Luc G. Elliott, Margaux Haon, Shahram Mesdaghi, Rebecca M. Price, Adam J. Simpkin, Daniel J. Rigden
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-01-01
Collection:	Computational and Structural Biotechnology Journal
Sujets:	Alphafold Structure prediction Beta-solenoid Model confidence Repeat proteins
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2001037025000200
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