Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.

The degradation of proteins by asparagine deamidation and aspartate isomerization is one of several chemical degradation pathways for recombinant antibodies. In this study, we have identified two solvent accessible degradation sites (light chain aspartate-56 and heavy chain aspartate-99/101) in the...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Katharina Diepold, Katrin Bomans, Michael Wiedmann, Boris Zimmermann, Andreas Petzold, Tilman Schlothauer, Robert Mueller, Bernd Moritz, Jan Olaf Stracke, Michael Mølhøj, Dietmar Reusch, Patrick Bulau
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Public Library of Science (PLoS) 2012-01-01
Σειρά:	PLoS ONE
Διαθέσιμο Online:	http://europepmc.org/articles/PMC3260267?pdf=render
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