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Multitargeting Pt(IV) Anticancer Prodrugs Bearing Mono- and Bis-Probenecid Ligands in Axial Positions: Synthesis and Evaluation of Biological Activity

<b>Background</b>: To battle the side effects of anticancer Pt(II) drug cisplatin, the development of photoactivatable and/or intracellular reduction-activatable Pt(IV) prodrugs has become a promising strategy. <b>Methods:</b> Herein, two novel Pt(IV) prodrugs, namely, <i>cis</i>,<i>cis</i>,<i>trans...

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Principais autores: Panxing Qiu, Yu Zhang, Yang Dou, Zhijin Cheng, Xiaoqin Wu, Silong Zhang, Fuyi Wang, Kui Wu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Pharmaceuticals
Fag:
Pt(IV) prodrug
probenecid
anticancer
metallodrug
multitargeting
Online adgang:https://www.mdpi.com/1424-8247/19/3/386
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