Role of the Mitochondrial Citrate-malate Shuttle in <i>Hras12V</i>-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis

The activation of the Ras signaling pathway is a crucial process in hepatocarcinogenesis. Till now, no reports have scrutinized the role of dynamic metabolic changes in <i>Ras</i> oncogene-induced transition of the normal and precancerous liver cells to hepatocellular carcinoma in vivo. In the curre...

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Hauptverfasser:	Chuanyi Lei, Jun Chen, Huiling Li, Tingting Fan, Xu Zheng, Hong Wang, Nan Zhang, Yang Liu, Xiaoqin Luo, Jingyu Wang, Aiguo Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-05-01
Schriftenreihe:	Metabolites
Schlagworte:	hepatocarcinogenesis <i>Ras</i> oncogene metabolomics transcriptomics mitochondrial citrate-malate shuttle
Online-Zugang:	https://www.mdpi.com/2218-1989/10/5/193
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