Scaffold Simplification Yields Potent Antibacterial Agents That Target Bacterial Topoisomerases

This work describes the lead optimization of a promising class of antibacterial compounds, derived from a previously reported N-[4-(4-fluorophenoxy)phenyl]-6-(methylsulfonyl)-2,6-diazaspiro [3.4]octane-8-carboxamide (<b>LK1819</b>), through systematic scaffold simplification. A novel series of amide...

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Auteurs principaux:	Lyubov Khudiakova, Kristina Komarova, Maxim Zhuravlev, Dmitry Deniskin, Alexey Golovanov, Artemiy Nichugovskiy, Kirill Babkin, Maria Zakharova, Mikhail Chudinov, Elizaveta Rogacheva, Lyudmila Kraeva, Olga Shevtsova, Daria Ipatova, Dmitry Skvortsov, Dmitrii Lukianov, Maxim Kryakvin, Maxim Gureev, Alexey Lukin
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2026-01-01
Collection:	Molecules
Sujets:	antibacterial agents scaffold simplification amino biphenyls amino diphenyl ethers ESKAPE pathogens DNA replication inhibitors
Accès en ligne:	https://www.mdpi.com/1420-3049/31/2/240
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