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Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol

Irinotecan (CPT11) chemotherapy-induced diarrhea affects a substantial cancer population due to β-glucuronidase (Gus) converting 10-O-glucuronyl-7-ethyl-10-hydroxycamptothecin (SN38G) to toxic 7-ethyl-10-hydroxycamptothecin (SN38). Existing interventions primarily address inflammation and Gus enzyme...

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Principais autores: Ruiyang Gao, Bei Yue, Cheng Lv, Xiaolong Geng, Zhilun Yu, Hao Wang, Beibei Zhang, Fangbin Ai, Ziyi Wang, Donghui Liu, Zhengtao Wang, Kaixian Chen, Wei Dou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-12-01
coleção:Acta Pharmaceutica Sinica B
Assuntos:
Irinotecan
Intestinal mucositis
β-Glucuronidase
Enterococcus faecalis
Intestinal stem cells
Epithelial regeneration
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221138352400385X
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