The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in Mycobacterium marinum

ABSTRACT The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 system-1) is a conserved protein secretion system requi...

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Hauptverfasser:	Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson, Rachel M. Cronin, Simon D. Weaver, Matthew M. Champion, Patricia A. Champion
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2024-05-01
Schriftenreihe:	mSphere
Schlagworte:	Mycobacterium ESX-1 PDIM secretion proteomics
Online-Zugang:	https://journals.asm.org/doi/10.1128/msphere.00005-24
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