Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhi...

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Detalhes bibliográficos

Principais autores:	Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C. Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-08-01
coleção:	Cell Reports
Assuntos:	glutamine glutamine synthetase macrophages succinate HIF1α metastasis IL-10 starvation metabolic rewiring
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124717310331
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