Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Magnesium ions (Mg2+) are divalent cations essential for various cellular functions. Mg2+ homeostasis is maintained through Mg2+ channels such as MgtE, a prokaryotic Mg2+ channel whose gating is regulated by intracellular Mg2+ levels. Our previous crystal structure of MgtE in the Mg2+-bound, closed...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Tatsuro Maruyama, Shunsuke Imai, Tsukasa Kusakizako, Motoyuki Hattori, Ryuichiro Ishitani, Osamu Nureki, Koichi Ito, Andrès D Maturana, Ichio Shimada, Masanori Osawa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2018-04-01
Schriftenreihe:	eLife
Schlagworte:	Mg2+ homeostasis Mg2+ channel MgtE gating mechanism NMR thermus thermophiles
Online-Zugang:	https://elifesciences.org/articles/31596
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