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Downregulation of miR-423-5p Contributes to the Radioresistance in Colorectal Cancer Cells

Resistance to radiotherapy is the main reason causing treatment failure in locally advanced rectal cancer. MicroRNAs (miRNAs) have been well demonstrated to regulate cancer development and progression. However, how miRNAs regulate radiotherapy resistance in colorectal cancer remains unknown. Herein,...

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Main Authors: Yuanyuan Shang, Lingfei Wang, Zhe Zhu, Wei Gao, Dan Li, Zhuqing Zhou, Lin Chen, Chuan-gang Fu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
rectal cancer
neoadjuvant radiotherapy
acquired radioresistance
miR-423-5p
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.582239/full
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