ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway. Within the endolysosomal pathway in mammalian cells, ESCRT complexes facil...
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| Hoofdauteurs: | , , , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
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Life Science Alliance LLC
2022-07-01
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| Reeks: | Life Science Alliance |
| Online toegang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202101239 |
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