Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

Hepatic ischemia-reperfusion injury (HIRI) is a significant complication of liver transplantation, often precipitating postoperative liver dysfunction/failure. Given the rising global prevalence of end-stage liver disease, which necessitates liver transplantation, protecting against HIRI is crucial....

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Principais autores:	Rasha A. Tawfiq, Yasmeen M. Attia, Hameis M. Sleem, Mai El-Sayed Ghoneim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
Colecção:	Frontiers in Pharmacology
Assuntos:	liver ferroptosis pyroptosis octreotide deferoxamine ischemia-reperfusion
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1610718/full
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