Synergistic elastase and papain injury drives abdominal aortic aneurysm formation and rupture in mice
Abstract Background Abdominal aortic aneurysm (AAA) rupture leads to high morbidity and mortality. Current rodent models struggle to reliably mimic infrarenal AAA rupture. Chemical treatments using pancreatic elastase (PE), papain (Pa), β-aminopropionitrile (BAPN), and angiotensin II (ANG II) are kn...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Portfolio
2026-03-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-026-01485-x |
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