Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL

Abstract: Ibrutinib has generated remarkable responses in patients with chronic lymphocytic leukemia (CLL), including those with an unfavorable cytogenetic profile. However, patients develop resistance, with poor outcomes and no established treatment options. Mutations in BTK and PLCG2 have emerged...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sabah Kadri, Jimmy Lee, Carrie Fitzpatrick, Natalie Galanina, Madina Sukhanova, Girish Venkataraman, Shruti Sharma, Brad Long, Kristin Petras, Megan Theissen, Mei Ming, Yuri Kobzev, Wenjun Kang, Ailin Guo, Weige Wang, Nifang Niu, Howard Weiner, Michael Thirman, Wendy Stock, Sonali M. Smith, Chadi Nabhan, Jeremy P. Segal, Pin Lu, Y. Lynn Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2017-05-01
Schriftenreihe:	Blood Advances
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2473952920301804
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