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A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis

Summary: During infections, host cells are exposed to pathogen-associated molecular patterns (PAMPs) and virulence factors that stimulate multiple signaling pathways that interact additively, synergistically, or antagonistically. The net effect of such higher-order interactions is a vital determinan...

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Principais autores: Skylar S. Wright, Chengliang Wang, Atri Ta, Morena S. Havira, Jianbin Ruan, Vijay A. Rathinam, Sivapriya Kailasan Vanaja
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-04-01
Serier:Cell Reports
Fag:
CP: Immunology
CP: Microbiology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124724003322
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