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The Inhibitory Effect of Protamine on Platelets is Attenuated by Heparin without Inducing Thrombocytopenia in Rodents

Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced...

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Principais autores: Joanna Miklosz, Bartlomiej Kalaska, Kamil Kaminski, Malgorzata Rusak, Krzysztof Szczubialka, Maria Nowakowska, Dariusz Pawlak, Andrzej Mogielnicki
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-09-01
Serier:Marine Drugs
Fag:
animal models
heparin
platelets
protamine
thrombocytopenia
thrombosis
Online adgang:https://www.mdpi.com/1660-3397/17/9/539
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