Transition state analogue of MTAP extends lifespan of APCMin/+ mice
Abstract A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5′-Methylthioadenosine (MTA), the...
Salvato in:
| Autori principali: | , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2021-04-01
|
| Serie: | Scientific Reports |
| Accesso online: | https://doi.org/10.1038/s41598-021-87734-6 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|