Development of a rapid HPLC-fluorescence method for monitoring warfarin metabolites formation: In vitro studies for evaluating the effect of piperine on warfarin metabolism and plasma coagulation

Warfarin, a widely prescribed anticoagulant, is highly effective for various coagulation disorders. However, its efficacy is limited by a narrow therapeutic index and frequent drug interactions, especially those involving metabolism by Cytochrome P450 (CYP450) enzymes. Piperine, found in black and l...

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Principais autores:	Aref L. Zayed, Mohammad Hadieh, Jomana Al Hroot, Fatima Hameedat, Sana'a A. Jaber
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-05-01
Series:	Heliyon
Assuntos:	Warfarin Metabolism Piperine Liver microsomes 7-Hydroxywarfarin Prothrombin time (PT)
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2405844024072979
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