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l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine (6-OHDA) in the lateral striatum. This type of lesion produced a dose-dependent depletion of DA fibers...

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Autori principali: Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2002-07-01
Serie:Neurobiology of Disease
Soggetti:
basal ganglia
behaviour
enkephalin
dynorphin
delta-fosB
sensitization
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996102904997
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