Binding of curcumin near the GBT440 binding site at the alpha cleft in the sickle cell hemoglobin model [Pdb ID: 1NEJ]
Introduction: In sickle cell anemia, deoxygenated HbS molecules polymerize into long fibers in the deep tissues during hypoxia. This leads to sickling of erythrocytes and clogging of capillaries and vessels. We are searching for new ligands like gbt440 that inhibit the HBS polymerization. Methods an...
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| Autore principale: | |
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| Natura: | Artigo |
| Lingua: | Inglês |
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Minia University, Faculty of Pharmacy
2024-04-01
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| Serie: | Journal of Advanced Biomedical and Pharmaceutical Sciences |
| Soggetti: | |
| Accesso online: | https://jabps.journals.ekb.eg/article_345876_8f57237a97573444a164c20bd892d06e.pdf |
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