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Losartan enhances the suppressive effect of pirfenidone on the bleomycin-induced epithelial-mesenchymal transition and oxidative stress in A549 cell line

Objective(s): Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease. Despite the promising anti-fibrotic effect, the toleration of pirfenidone (PFD) by the patients in full dose is low. Combination therapy is a method for enhancing the therapeutic efficiency of PFD and decreasing its dose. The...

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Principais autores: Arian Amirkhosravi, Mahmoudreza Heidari, Somayyeh Karami-Mohajeri, Maryam Torshabi, Ali Mandegary, Mehrnaz Mehrabani
Formato: Artigo
Idioma:Inglês
Publicado em: Mashhad University of Medical Sciences 2023-08-01
coleção:Iranian Journal of Basic Medical Sciences
Assuntos:
bleomycin
epithelial-mesenchymal - transition
idiopathic pulmonary - fibrosis
losartan
oxidative stress
pirfenidone
Acesso em linha:https://ijbms.mums.ac.ir/article_22385_cca1a3ab9575f723e5d58c86c6ec0f65.pdf
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