IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2

Abstract Drivers of therapeutic resistance in cancer include evolving tumor cell heterogeneity and the tumor microenvironment (TME). We find that increased matrix stiffness promotes radioresistance in glioblastoma (GBM) and maintains tumor cell hierarchies. Differential gene expression reveals that...

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Hauptverfasser:	Po Zhang, Weichi Wu, Tengfei Huang, Xujia Wu, Donghai Wang, Huairui Yuan, Suchet Taori, Fanen Yuan, Frank P. Vendetti, Rui Wang, Tingting Duan, Hailong Mi, Huan Li, Kailin Yang, Daqi Li, Ahmed Habib, Briana C. Prager, Ryan C. Gimple, Pascal O. Zinn, Kalil Abdullah, Christopher Bakkenist, Junran Zhang, Qiulian Wu, Jeremy N. Rich
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-06-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-026-74058-0
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