Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C>T; p.(Thr542Ile)) are known individually, h...

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Detalhes bibliográficos

Principais autores:	Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Karger Publishers 2023-03-01
coleção:	Journal of Innate Immunity
Assuntos:	genetic complement variants complement imbalance complement reconstitution
Acesso em linha:	https://www.karger.com/Article/FullText/528607
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