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Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution

Abstract Nullomers and nullpeptides are short DNA or amino acid sequences that are absent from a genome or proteome, respectively. One potential cause for their absence could be their having a detrimental impact on an organism. Results Here, we identify all possible nullomers and nullpeptides in the...

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Principais autores: Ilias Georgakopoulos-Soares, Ofer Yizhar-Barnea, Ioannis Mouratidis, Martin Hemberg, Nadav Ahituv
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-08-01
Serier:Genome Biology
Fag:
Nullomers
Nullpeptides
Primes
Negative selection
Transposable elements
Human population
Online adgang:https://doi.org/10.1186/s13059-021-02459-z
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